Research

The lab specialises in computational biology, functional genomics, and non-invasive diagnostics. With a focus on the computational and statistical analyses of the RNA, protein, and metabolites produced by healthy and unhealthy tissues/cell-types we define markers of various diseases that can be detected in blood, urine, and cerebrospinal fluid. We apply state-of-the-art statistical/machine-learning approaches and leverage the massive power and flexibility of cloud-computing to define novel biomarkers of cardiovascular disease, type 2 diabetes, neurodegenerative diseases, and various cancers. Recently the lab have become active contributors to Mass-General Brigham’s COVID-19 Innovation effort, helping to evaluate low-cost serologic (antibody/immunity) and diagnostic (viral RNA/protein detection) technologies before they are deployed to the greater Boston area and beyond.

Software & Data

News & Publications

COVID-19 antibody test performance

In an effort to support the work evaluating technologies for serology (antibody) testing, the lab has developed an interactive webapp to explore the effect of changing prevalence on the population-level performance of these tests.

miRNA Tissue Atlas

Good RNA biomarkers may be specifically expressed in tissues relevant to the disease under investigation. In collaboration with the van Keuren-Jensen lab at TGen, we have created a human small-RNA tissue atlas.

Lab & People

Current lab members, including visiting students

Contact

Our lab is based in the Cardiovascular Research Center (CVRC)
at Massachusetts General Hospital and Harvard Medical School.

About us

The Kitchen Laboratory specialises in computational biology, functional genomics, and non-invasive diagnostics. We apply state-of-the-art statistical/machine-learning approaches and leverage the massive power and flexibility of cloud-computing to define novel biomarkers of cardiovascular disease, type 2 diabetes, neurodegenerative diseases, and various cancers.

Contact Info

Address
CVRC • 149 13th St Charlestown, MA 02129 • USA
Phone
(617) 643-3449
Email
rkitchen@mgh.harvard.edu