Research
The laboratory specialises in computational biology, functional genomics, and non-invasive diagnostics. With a focus on the computational and statistical analyses of the RNA, protein, and metabolites produced by healthy and unhealthy tissues/cell-types we define markers of various diseases that can be detected in blood, urine, and cerebrospinal fluid. We apply state-of-the-art statistical/machine-learning approaches and leverage the massive power and flexibility of cloud-computing to define novel biomarkers of cardiovascular disease, type 2 diabetes, neurodegenerative diseases, and various cancers. Recently the lab have become active contributors to Mass-General Brigham’s COVID-19 Innovation effort, helping to evaluate low-cost serologic (antibody/immunity) and diagnostic (viral RNA/protein detection) technologies before they are deployed to the greater Boston area and beyond.